pentobarbital will reduce the extent or influence of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will lessen the extent or result of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lack of, or lowered reaction to tofacitinib may well come abo